Prion's progress
نویسندگان
چکیده
منابع مشابه
Prions: Current Progress in Advanced Research
This 134-page book provides a brief but wide-ranging overview of current research into prions, the infectious proteinaceous agents believed to be responsible for a range of fatal, neurodegenerative diseases including “mad cow” disease and Creutzfeldt-Jakob disease. Divided into 11 chapters, the book covers topics such as prion biology, disease pathogenesis, and strategies for vaccination and tr...
متن کاملPrions.
The discovery of infectious proteins, denoted prions, was unexpected. After much debate over the chemical basis of heredity, resolution of this issue began with the discovery that DNA, not protein, from pneumococcus was capable of genetically transforming bacteria (Avery et al. 1944). Four decades later, the discovery that a protein could mimic viral and bacterial pathogens with respect to the ...
متن کاملPrions.
Infectious proteins (prions) are usually self-templating filamentous protein polymers (amyloids). Yeast prions are genes composed of protein and, like the multiple alleles of DNA-based genes, can have an array of "variants," each a distinct self-propagating amyloid conformation. Like the lethal mammalian prions and amyloid diseases, yeast prions may be lethal, or only mildly detrimental, and sh...
متن کاملPrions
plants are cloaked in hundreds of tiny projections, known as trichomes. These structures vary in function, shape, size and spacing from species to species, and it’s not known whether similar cellular differentiation programs are responsible for making trichomes in different plants. Trichomes are clearly visible in the scanning electron micrograph of a wild-type Nicotiana tabacum seedling above ...
متن کاملAnimal Prions Are a New Type of Infectious Agents Prions
Prions were originally defined as infectious agents of protein nature, which caused neurodegenerative diseases in animals and humans. The prion concept implies that the infectious agent is a protein in special conformation that can be transmitted to the normal molecules of the same protein through protein–protein interactions. Until the 1990s, the prion phenomenon was associated with the single...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2004
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb0904-798